Monday, May 25, 2020

Alzheimer s Disease Genetic Analysis - 1129 Words

Alzheimer’s Disease: Genetic Analysis Introduction Alzheimer’s disease (AD) is a profoundly common form of degenerative dementia that is caused by neurofibrillary tangles and amyloid plaques accumulating in the brain (Sennvik et.al., 2000). The study of the human genome has elucidated gene variants; single nucleotide polymorphisms (SNPs) and mutations which affect the age of onset and the likelihood of developing AD. Understanding the causes of familial AD, the genetic risk factors for AD and the links between AD and other disorders; such as Down’s syndrome, will aid researchers in the diagnosis and treatment of AD. Familial Alzheimer ’s disease Familial Alzheimer’s disease (FAD) is the inheritable genetic predisposition to early-onset AD.†¦show more content†¦This promotes the aggregation of amyloid plaques and causes early-onset of FAD. Presenilin 1 Presenilin 2 PSEN1 and PSEN2 are polytopic membrane proteins (Davis et.al., 1998) that form the catalytic core in the protease ÃŽ ³-secretase (Francis et.al., 2002), which is responsible for the proteolysis of APP (Navivaeva Turner, 2013). When there is a mutation at the loci for PSEN1 and PSEN2, located on chromosome 14 and 1 respectively, the activity of ÃŽ ³-secretase is altered resulting in changes in the proteolysis of APP and increased formation of AÃŽ ² (Qain et.al., 1998). Due to the increase of AÃŽ ², amyloid plaques aggregate quickly causing early-onset of AD. Amyloid Plaques and Down’s Syndrome Down’s syndrome has distinct phenotypic features which include the aggressive early-onset of AD. This is due to the location of the APP gene; on chromosome 21. The protein APP is triplicated due to the trisomy of chromosome 21 (Wisniewski et.al., 1985). The triplication of the APP gene causes an overexpression of APP; 1.5 times more protein is produced compared to persons with two copies of the APP gene. This ultimately results in high quantities of amyloid plaques due to the larger quantity of AÃŽ ² produced. Risk Factors for Alzheimer’s Disease While genetic mutations in proteins such as APP and presenilins have been revealed to cause deterministic

Thursday, May 14, 2020

The Rise of African-Americans from 1865 to 2012, Their...

Running Head: The Rise of African- Americans From 1865 To 2012, Their Struggles To Become Free Americans THE RISE OF AFRICAN-AMERICANS FROM 1865 TO 2012, THEIR STRUGGLES TO BECOME FREE AMERICANS Brenda Maynard HIS204: American History Since 1865 (GSN1241A) Instructor: Tracy Samperio Ashford University October29, 2012 The Rise of African- Americans The Rise of African- Americans From 1865 To 2012, Their Struggles To Become Free Americans After the Civil War African-American expected to have their freedom, but this was not really the case. Even though the approval of the 13th Amendment freed them from their Southern masters, they were still far from being free. The 13th amendment to the United States Constitution provides that†¦show more content†¦Most northern white people and black people lived in different neighborhoods and attended different schools. This segregation resulted from African Americans resided in distinctive neighborhoods, because of low incomes well as wanting to live near other African Americans. It also caused them to be isolated within the cities and towns they lived in. Many blacks separated themselves not as a matter of choice or custom. Landlords were not fond of renting to black people and often The Rise of African- Americans turned them away. Realtors directed blacks away from white neighborhoods. Often municipal ordinances kept blacks out of white areas. Blacks were prevented from moving freely from town to town. They also could not be caught out at night without an explicit reason. Organizations such as the Ku Klux Klan, The White Brotherhood, the Red Shirts, and Knights of the White Camelia generated fear and oppression within the black community. â€Å"Klan members burned black homes, schools and churches as a reminder that blacks should not challenge white supremacy (POWELL, 2008, Mar 09). These organizations prevented Blacks from voting. Because state laws made it illegal for Blacks to own gun, blacks had no way to defend themselves. Klan members tended gang up on their victims. Because of the Ku Klux Klan and others like them, African Americans feared for their lives on a daily bases. In 1871 Congress passed the Force Bill, giving the federal governmentShow MoreR elatedReconstruction Document Analysis1256 Words   |  6 PagesDr. Wheeler HIS 251 26 November 2012 Document Analysis: â€Å"Reconstruction: Clashing Dreams and Realities, 1865-1868† The Civil War brought with it destruction in the South, over 600,000 fatalities, economic devastation, and a nation hanging together by the thread of the hopes of those who believed that the nation of Washington would not â€Å"perish from the earth.† Those living in the losing side had to face the harsh realities that their lives would never be the same, both for the white slave ownersRead MoreEssay about Individualism in American History1470 Words   |  6 PagesThe Struggle to Be Unique Do you stand alone as a unique and special individual? Since the beginning of American history there have been struggles for individualism. The American Revolution, the American Civil War, and the separation from family life are all examples of individualism in American history. Individualism is an American paradigm designed by the modern societal structure that is an altered idea of the foundation by immigrants. In today’s society the struggle for individualism is moreRead MoreA History of African Americans after Reconstruction Essay2543 Words   |  11 PagesHistory of African Americans after Reconstruction During reconstruction the United States was divided on social issues, presidential campaigns were won and loss on these issues during this period. The struggle for development of African Americans and how they initiated change in political, economic, educational, and social conditions to shape their future and that of the United States. (Dixon, 2000) The South’s attempts to recover from the Civil war included determining what to do with newly freedRead MoreThe Effects of Incarceration Discrimination in the United States for African American Men2898 Words   |  12 Pagesprogression within society is a trend that engulfs African American men constantly in the American society. There is a continuous struggle to break the persistent mold. Although many feel that the United States has overcome its racist history, the legacies of slavery and racism still affect our policies and practices today. Of the nearly 2.1 million adult men and women imprisoned in the United States, roughly 70% are persons of color (Minton, 2012). Within the criminal justice system, people of colorRead MoreThe Broken Promise of Reconstruction the Need for Restitution5574 Words   |  23 PagesRESTITUTION The Civil War is the most widely written about event in American history and Reconstruction is the most mis-understood and least appreciated subject within this wider issue. Most people would prefer to escape into the heroic exploits of the battles that were fought than deal with the difficult social problems that the former enslaved population had to deal with. I am offering this essay since I believe that the African-Americans have been done a great disservice by the Nation. As a people theyRead MoreASAM 5 Notes Essay6590 Words   |  27 Pagescore as. Three parts Minority Literature Minority literature The concept of minority has been central to the very founding of American life and government Metaphors of minorities Invisibility : lock of recognition Notion of otherness: radical difference WEB Dubois, the souls of Black Folk (1903) Historian and writer First African American to receive PhD from Harvard Two primary ideas :The problem of the 20th century is the problem of the color line. Double consciousness Double consciousness Read MoreExploring Corporate Strategy - Case164366 Words   |  658 Pagesstrategic issues of speciï ¬ c organisations in much greater depth – and often providing ‘solutions’ to some of the problems or difï ¬ culties identiï ¬ ed in the case. There are also over 33 classic cases on the Companion Website. These are a selection of cases from recent editions of the book which remain relevant for teaching. The case studies are intended to serve as a basis for class discussion and not as an illustration of either good or bad management practice. They are not intended to be a comprehensive

Wednesday, May 6, 2020

Dramatic Symbolism - 1051 Words

Symbolisms were used in the Old Testament to distinguish between good and evil. The symbols portray a likeness between the entities used as a symbol and usually have a parallel to follow. Symbols can be drawn from historical and/or cultural backgrounds. Apocalyptic literature popularly applied to a group of fourteen books whose place in the canon of the Old Testament is affirmed by the Roman Catholic Church but is denied by Protestant Churches. The period of transition and decay followed the return of the Jews from Babylon, being written chiefly, if not entirely, between 300 and 30 BC. A few of the outstanding characteristics are the absence of the prophetic element, a somewhat romantic treatment of the past, involving errors, and†¦show more content†¦Within the tabernacle, the Israelites were instructed to make a veil woven of blue, purple, and scarlet (Exodus 26:31). Purple being the chosen color for royalty brings out the reasoning for the color used for the clothing of Jesus’ robe as written in Mark 15:17. Purple was also the color used for Mordecai’s apparel (Esther 8:15) and Ahasuerus’ palace (Esther 1:6). The attractive color of Scarlet placed it next to Purple as a symbol of wealth and station. It was used in the hangings of the tabernacle, in the priestly garments and for certain ceremonies (Exodus 26:1, 28:6; Numbers 19:6). Scarlet clothing was a sign of prosperity (2 Samuel 1:24; Proverbs 31:21). Its brilliance made it an example for all that is glaring, for instance, the sins of Israel (Isaiah 1:18). Vermillion is a bright red paint used for painting houses and idols (Jer. 22:14; Ezek. 23:14). Scholars reflect their meanings according to scripture have described other colors that are not mentioned in the Bible. Red for instance is the color of blood. Among primitive races, including Hebrews, blood was regarded with religious awe. It was believed by the Hebrews to be the seat of the soul, the principle of Life itself. In the light of this conception of blood are to be understood the manifold social and religious customs, including sacrifice, which were practiced by the Israelites. Therefore, Red can have a meaningfulShow MoreRelatedAustralian Theater Ruby Moon and Stolen1413 Words   |  6 Pagesvarious performance styles, techniques and dramatic conventions to help portray their ideas to their audiences and make them feel a particular way to the ideas presented in a play. Without the use of these styles, techniques and conventions it wouldn’t be possible for the practitioners to emphasise their ideas.   Ruby Moon, a mysterious and eerie play written by Matt Cameron explores presentational theatre aspects and elements of absurdism. Cameron has used dramatic forms, performance styles, techniquesRead MoreThe Cherry Orchard Essay751 Words   |  4 Pagespoetic, the language used in modernist literature is explicit. Anton Chekhov’s â€Å"The Cherry Orchard† is an example of Modern literature because it tosses aside traditional structures and theatrical conventions. The play’s four act structure and the symbolism of the setting both exemplify examples of modernism in literature. The four act structure of â€Å"The Cherry Orchard† is an example of modernism because it rejects the traditional five act structure used in romanticism. Chekhov uses each act to representRead MoreSymbolism In Ibsens A Dolls House1173 Words   |  5 Pagesdrama, symbolism is one of the important literary devices that is commonly employed by many play writers. It imparts the play’s hidden meaning and portrays emotions and conflicts in the characters. Equally, Ibsen’s play, A Doll House makes an extensive use of symbols which does not only make the play captivating but also enables the reader to get a deeper understanding of the underlining ideas. Indeed, Symbolism is a literary device that is evident throughout Ibsen s play. Examples of symbolism in theRead MoreEmily Dickinson s Poems Are About Death1239 Words   |  5 Pagesdeath. Emily Dickinson was a very figurative, but at the same time very literal, poet. She often used symbolism, personification, repetition, and alliteration. For example, in Because I could not stop for Death she uses the carriage to symbolize the final passage to death. This is clearly illustrated by the fact that death is riding in the carriage with the speaker. She also uses symbolism when she talks about the sunset, the house, and her gown and tippet(shawl). She uses the sunset to symbolizeRead MoreSymbolism In Ibsens A Dolls House1187 Words   |  5 PagesComposition II 10/19/17 Symbolism in A Doll House Introduction In a drama, symbolism is one of the important literary devices that is commonly employed by many play writers. It imparts the play’s hidden meaning and portrays emotions and conflicts in the characters. Equally, Ibsen’s play, A Doll House makes an extensive use of symbols which does not only make the play captivating but also enables the reader to get a deeper understanding of the underlining ideas. Indeed, Symbolism is a literary deviceRead MoreHills Like White Elephants1354 Words   |  5 PagesSymbolism in â€Å"Hills Like White Elephants† Ernest Hemingway’s â€Å"The Hills Like White Elephants† is a short story published in 1927 about an American man and a woman named Jig. The setting of this story takes place at a train station located in Spain surrounded by hills, trees, and fields. Other devices used by Hemingway throughout this story include imagery, simile, excellent syntax, and a very tense and emotional tone. In the beginning of the story, the American and Jig sit outside of the trainRead MoreSymbolism in The Playboy of the Western World Essay715 Words   |  3 PagesSymbolism in The Playboy of the Western World Symbols are a powerful way of conveying information and feelings by substituting something concrete to represent an idea e.g. the heart (love), the dove (peace). Such representation is called symbolism. In writing The Playboy of the Western World, Synge serves us an Irish delicacy, in which lies the subtle yet memorable flavour of symbolism, in the midst of rollicking comedy and luscious language. The play opens withRead MoreSymbolism Of The Story Of An Hour By Kate Chopin945 Words   |  4 PagesSymbolism in â€Å"The Story of an Hour† In her piece â€Å"The Story of an Hour,† Kate Chopin uses several symbols to bring Louise Mallard’s dramatic hour to life, as well as the themes of freedom and disillusionment that come with marriage and life. Chopin used Mrs. Mallard’s heart trouble, the open window and spring life, and her final descent down the stairs that led to her death to show that Louise’s marriage to Brently was suffocating her free spirit and decreasing her quality of life. These main symbolsRead MorePursuit of Happiness1081 Words   |  5 PagesngÆ °Ã¡ » i thá º ¥y cá º §n bá »â€¢ sung hay cá º ¯t bá »â€ºt gà ¬ thà ¬ cá » © cmt nhà © :D 7 tià ªu chà ­ gá »â€œm: - Plot - Character (Character vá »â€ºi Plot tui cho luà ´n và  o Overview nhà © ko sá » £ mn lá º ¡i thá º ¯c má º ¯c sao ko Ä‘á » § 7 má » ¥c) - Setting - Point of view - Style- Tone- Language - Themes - Symbolism Cà ²n Ä‘Ã ¢y dà  n à ½. Tà ´i há » i cà ´ thà ¬ cà ´ bá º £o là ºc nà  o cÃ… ©ng phá º £i cà ³ Overview á »Å¸ Ä‘á º §u cho nhá » ¯ng bá º ¡n chÆ °a Ä‘á » c truyá »â€¡n cÃ… ©ng hiá »Æ'u Ä‘c. 1. Overview: - Mà ¬nh sá º ½ phá º £i nà ³i qua vá »  summary cá » §a truyá »â€¡n (1 cà ¡ch ngá º ¯n gá » n, sà ºc tà ­ch và   dá »â€¦ hiá »Æ'u nhá º ¥t cà ³ thá »Æ' – cà ¡i nà  y tà ´i thá º ¥yRead More The Transformation of Edna Pontellier in The Awakening Essay950 Words   |  4 Pageslearning to swim is a significant experience because it shows how she is able to gain control over her body: â€Å"The voice of the sea speaks to the soul† (Chopin). This is a powerful statement due to the fact that it represents how Edna undergoes a dramatic change in character. She goes from listening and acting upon the influences of society, to following her own mind and innermost desires. These both play a large part in understanding Edna’s personal transformation from a quiet and fearful girl

Tuesday, May 5, 2020

A Legal Struggle

Question: Analyze the research in order to determine who was ethically correct in your opinion; the husband or the parents. Answer: Introduction Terri Schiavo underwent a legal struggle regarding the right to end her life when she remained in a vegetative state for nearly fifteen years. She was under a strict diet and collapsed one fine morning. The doctors extended her treatment but she went into a permanent vegetative state from which she could never recover. After a few years of her treatment, her husband claimed that her feeding tube should be removed and it should be allowed to her that she should end her life because had she been alive, she would have never agreed to such a life. On the other hand, her parents were totally against the removal of her life support and claimed that the plea was being made by her husband so that he could utilize the money he had received against medical malpractice for his own benefits. In this situation, after a lot of stifle, the court finally agreed to allow Michael Schiavo, husband of Terri Schiavo to put an end to the life of Terri (Miller, 2015). Ethical Standards There are arguments on both sides of this matter. While the husband was correct on making a plea, the parents were also correct on the issue. As far as the ethical standards are in question, it can be said that if the feeding tube would have been removed many years back, there would have been no unethical act done. Terri was already in a vegetative state and the doctors had very clearly explained that there are no chances of her revival (KRUSE, 2015). As such, there are no evidences that her life span would have shortened and hence ethically, she would not have been killed. Rather, she would have been allowed to put an end to her sufferings. It also makes economic sense because either way, she had become a non productive resource or she was of no good for the nation. Rather, if the feeding tube would have been removed earlier, it would have saved a lot of economic expenditure and at the same time, the medical resources spent on her could have been used for some other purposes. The Hi ppocratic Oath of the doctors would not have suffered and there would have been no harm on anyone. The alternative treatment that was given to Terri was equally horrifying and her vegetative state showed no signs of improvement. She was constantly being fed through tubes and channels which no human being likes. As such, her condition was so worse that her husband was right in requesting to allow for the removal of her feeding tube. On the other hand, her parents were somewhat justified in claiming that she should be allowed to live. Being parents, it is obvious that they could not bear to see their daughter succumb to death. With the Divine power, it is said that one should never lose hope (Sanburn, 2015). Hence, as parents they were right in expecting that she will come back to normal life in due course. Analysis However, it must not be ignored in this respect that the claim was raised by her parents because of the money received by Michael for medical malpractice. Michael was not ethically wrong because he extended all that he could do to improve her condition. He was also appointed as the official guardian of Terri and hence, he had all the rights to take decisions about her when she was incapacitated to decide on her life. Michael had done nothing wrong in taking this decision (Terrisfight.org, 2015). On the other hand, her parents it is quite evident that her parents wanted her to live so that they could stop Michael from utilizing the money for personal benefits. But, the trial Court as well expressed the view that if Terri was normal in the present day, she would have never agreed to this kind of a lifestyle that she was presently in. the brain scans of Terri clearly showed that considering her potassium levels there was nothing in the medical science as well that could improve her condition (WND, 2015). She was a person who was very sophisticated and was particular about her own beauty and own self. She could in no way agree to keep a life where she was simply alive by a miniscule machine and there was nothing else in her life. As such, it is argued that her husband was right in appealing for her removal of life support and allowing him so that he could put an end to her life thus bringing peace to many people (Miami.edu, 2015). The matter would have been a bit difficult for t he parents in the initial stages but slowly, even they would have accepted the reality. Conclusion Thus, ethically, it can be said that while there is nothing wrong in the legal standards regarding the death of Terri, the same is morally correct as well. Personal view is that Michael Schiavo was correct in making the plea and convincing the Court. Had the incident taken place many years back, things would have been much happier. References KRUSE, M. (2015).Jeb 'Put Me Through Hell.POLITICO Magazine. Retrieved 24 August 2015, from https://www.politico.com/magazine/story/2015/01/jeb-bush-terri-schiavo-114730.html#.Vdrs5fmqqko Miami.edu,. (2015).Schiavo Timeline, Part 1 | Ethics | University of Miami. Retrieved 24 August 2015, from https://www.miami.edu/index.php/ethics/projects/schiavo/schiavo_timeline/ Miller, Z. (2015).Jeb Bush: No Regrets on Terri Schiavo.TIME.com. Retrieved 24 August 2015, from https://time.com/3826605/jeb-bush-terri-schiavo/ Sanburn, J. (2015).How Terri Schiavo Shaped the Right-to-Die Movement.TIME.com. Retrieved 24 August 2015, from https://time.com/3763521/terri-schiavo-right-to-die-brittany-maynard/ Terrisfight.org,. (2015).Terri Schiavo Life Hope Network. Retrieved 24 August 2015, from https://www.terrisfight.org/ WND,. (2015).10 years later, Terri Schiavos death still haunts. Retrieved 24 August 2015, from https://www.wnd.com/2015/03/10-years-later-terri-schiavos-death-still-haunts/